The effects of alpha-lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials. Moreover, the duration of treatment appears to influence a person's body mass index (BMI), but not the person's actual weight. In the United States, about 20 million people suffer from peripheral neuropathy, according to Medicalnewstoday.com 1. An alpha-lipoic acid deficiency is practically unheard of. Although we strive to deliver accurate and up-to-date information, no guarantee to that effect is made. However, the key difference between lipoic acid and alpha lipoic acid is that the lipoic acid, in its natural form, is the R isomer whereas alpha lipoic acid is a mixture of R isomer and S isomer. Good sources of ALA are yeast and liver.1, 2 Other sources include spinach, broccoli, potatoes, kidney, heart, and skeletal muscle.3 ALA is an 8-carbon sulfur containing fatty acid that has the International Union of Pure and Applied Chemistry name of 5-([3R]-dith… Neuropathy is the medical term used to describe the pain, numbness, and abnormal sensations caused by nerve damage. Thank you, {{form.email}}, for signing up. Alpha-lipoic acid also serves as an antioxidant that can work to neutralize harmful free radicals throughout the body, according to the University of Maryland Medical Center 2. Effects of alpha-lipoic Acid on body weight in obese subjects. Alpha lipoic acid (ALA) is a fat-soluble, sulfur-containing, vitamin-like antioxidant. Alpha lipoic acid supplements are becoming increasingly popular with people who are looking to get more antioxidants, combat symptoms of diabetes and diabetic neuropathy, slow the damage done by liver disease or HIV, or to boost brain power. This includes diabetes, multiple sclerosis, cardiovascular ailments, cancer, AIDS, and Alzheimer's, among many others. Glaucoma and Alpha Lipoic Acid – Forty-five patients with stage I and II open-angle glaucoma (OAG) were administered either 75 mg of alpha-lipoic acid for 2 months or 150 mg for 1 month. For maximum absorption, the supplements should be taken on an empty stomach. In the November 2006 issue of "Diabetes Care," researchers describe a clinical trial of orally administered alpha-lipoic acid 3. Alpha-lipoic acid is a naturally occurring fatty acid that can be found in many foods such as yeast, spinach, broccoli, potatoes, and organ meats such as liver or kidney. ALA functions in the same manner as many B-complex vitamins. Alpha-lipoic acid is a compound found naturally inside every cell of the human body. Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases, The effects of alpha-lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials, Amelioration of lipid abnormalities by α-lipoic acid through antioxidative and anti-inflammatory effects, Alpha lipoic acid for symptomatic peripheral neuropathy in patients with diabetes: a meta-analysis of randomized controlled trials, Alpha-lipoic acid (ALA) as a supplementation for weight loss: results from a meta-analysis of randomized controlled trials, Effects of alpha-lipoic Acid on body weight in obese subjects, Development and characterization of new topical hydrogels based on alpha lipoic acid—hydrotalcite hybrids, A rare cause of status epilepticus; alpha lipoic acid intoxication, case report and review of the literature, Effects of dietary L-carnosine and alpha-lipoic acid on growth oerformance, blood thyroid hormones and lipid profiles in finishing pigs, A systematic review and meta-analysis of α-lipoic acid in the treatment of diabetic peripheral neuropathy. There have, in fact, been several reports of seizures and vomiting in children who have taken doses of 2,400 mg or greater.. In the February 2004 issue of "Diabetic Medicine," researchers describe their meta-analysis of clinical data on the intravenous treatment of diabetic neuropathy with alpha-lipoic acid 3. With that being said, there is growing evidence that alpha-lipoic acid can influence weight, albeit modestly. 2015;19(6):730-2. doi:10.1016/j.ejpn.2015.07.002, Bao Y, Gao C, Hao W, et al. A 2018 systematic review and meta-analysis of 20 randomized controlled trials of people with metabolic disorders (some had type 2 diabetes, others had other metabolic disorders) found that lipoic acid supplementation lowered fasting blood glucose, insulin concentration, insulin resistance, and blood hemoglobin A1c levels.. 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